Immunoregulatory roles of versican proteolysis in the myeloma microenvironment

Myeloma immunosurveillance remains incompletely understood. We have demonstrated proteolytic processing of the matrix proteoglycan, versican (VCAN), in myeloma tumors. Whereas intact VCAN exerts tolerogenic activities through Toll-like receptor 2 (TLR2) binding, the immunoregulatory consequences of...

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Veröffentlicht in:Blood
Hauptverfasser: Hope, Chelsea, Foulcer, Simon, Jagodinsky, Justin, Chen, Sarah X., Jensen, Jeffrey L., Patel, Sanjay, Leith, Catherine, Maroulakou, Ioanna, Callander, Natalie, Miyamoto, Shigeki, Hematti, Peiman, Apte, Suneel S., Asimakopoulos, Fotis
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2016
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974200/
https://ncbi.nlm.nih.gov/pubmed/27259980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-03-705780
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