Immunoregulatory roles of versican proteolysis in the myeloma microenvironment

Myeloma immunosurveillance remains incompletely understood. We have demonstrated proteolytic processing of the matrix proteoglycan, versican (VCAN), in myeloma tumors. Whereas intact VCAN exerts tolerogenic activities through Toll-like receptor 2 (TLR2) binding, the immunoregulatory consequences of...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Hope, Chelsea, Foulcer, Simon, Jagodinsky, Justin, Chen, Sarah X., Jensen, Jeffrey L., Patel, Sanjay, Leith, Catherine, Maroulakou, Ioanna, Callander, Natalie, Miyamoto, Shigeki, Hematti, Peiman, Apte, Suneel S., Asimakopoulos, Fotis
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974200/
https://ncbi.nlm.nih.gov/pubmed/27259980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-03-705780
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