TPL2 kinase regulates the inflammatory milieu of the myeloma niche

Targeted modulation of microenvironmental regulatory pathways may be essential to control myeloma and other genetically/clonally heterogeneous cancers. Here we report that human myeloma–associated monocytes/macrophages (MAM), but not myeloma plasma cells, constitute the predominant source of interle...

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Autori principali: Hope, Chelsea, Ollar, Samuel J., Heninger, Erika, Hebron, Ellen, Jensen, Jeffrey L., Kim, Jaehyup, Maroulakou, Ioanna, Miyamoto, Shigeki, Leith, Catherine, Yang, David T., Callander, Natalie, Hematti, Peiman, Chesi, Marta, Bergsagel, P. Leif, Asimakopoulos, Fotis
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2014
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046426/
https://ncbi.nlm.nih.gov/pubmed/24723682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-02-554071
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