TPL2 kinase regulates the inflammatory milieu of the myeloma niche

Targeted modulation of microenvironmental regulatory pathways may be essential to control myeloma and other genetically/clonally heterogeneous cancers. Here we report that human myeloma–associated monocytes/macrophages (MAM), but not myeloma plasma cells, constitute the predominant source of interle...

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Bibliografiske detaljer
Main Authors: Hope, Chelsea, Ollar, Samuel J., Heninger, Erika, Hebron, Ellen, Jensen, Jeffrey L., Kim, Jaehyup, Maroulakou, Ioanna, Miyamoto, Shigeki, Leith, Catherine, Yang, David T., Callander, Natalie, Hematti, Peiman, Chesi, Marta, Bergsagel, P. Leif, Asimakopoulos, Fotis
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2014
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046426/
https://ncbi.nlm.nih.gov/pubmed/24723682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-02-554071
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