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Pharmacokinetics of lamotrigine and its metabolite N‐2‐glucuronide: Influence of polymorphism of UDP‐glucuronosyltransferases and drug transporters

AIMS: This study aimed to develop a population pharmacokinetic model for quantitative evaluation of the influence of genetic variants in metabolic enzymes and transporters on lamotrigine pharmacokinetics while taking into account the influence of various clinical, biochemical and demographic factors...

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Foilsithe in:Br J Clin Pharmacol
Main Authors: Milosheska, Daniela, Lorber, Bogdan, Vovk, Tomaž, Kastelic, Matej, Dolžan, Vita, Grabnar, Iztok
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972156/
https://ncbi.nlm.nih.gov/pubmed/27096250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12984
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