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Stereoselective Covalent Adduct Formation of Acyl Glucuronide Metabolite of Nonsteroidal Anti-Inflammatory Drugs with UDP-Glucuronosyltransferase

A reactive metabolite of nonsteroidal anti-inflammatory drugs (NSAIDs), acyl-β-D-glucuronide (AG), covalently binds to endogenous proteins. The covalent adduct formation of NSAIDs-AG may lead to the dysfunction of target proteins. Therefore, it is important to clarify the detailed characterization o...

詳細記述

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書誌詳細
主要な著者: Atsushi Kawase, Rio Yamashita, Tsubasa Yoshizato, Mashiro Yoshikawa, Hiroaki Shimada, Masahiro Iwaki
フォーマット: Artigo
言語:Inglês
出版事項: MDPI AG 2022-04-01
シリーズ:International Journal of Molecular Sciences
主題:
オンライン・アクセス:https://www.mdpi.com/1422-0067/23/9/4724
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