Eradication of acute myeloid leukemia with FLT3 ligand-targeted miR-150 nanoparticles

Acute myeloid leukemia (AML) is a common and fatal form of hematopoietic malignancy. Overexpression and/or mutations of FLT3 have been shown to occur in the majority cases of AML. Our analysis of a large-scale AML patient cohort (n=562) indicates that FLT3 is particularly highly expressed in some su...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Jiang, Xi, Bugno, Jason, Hu, Chao, Yang, Yang, Herold, Tobias, Qi, Jun, Chen, Ping, Gurbuxani, Sandeep, Arnovitz, Stephen, Strong, Jennifer, Ferchen, Kyle, Ulrich, Bryan, Weng, Hengyou, Wang, Yungui, Huang, Hao, Li, Shenglai, Neilly, Mary Beth, Larson, Richard A., Le Beau, Michelle M., Bohlander, Stefan K., Jin, Jie, Li, Zejuan, Bradner, James E., Hong, Seungpyo, Chen, Jianjun
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970973/
https://ncbi.nlm.nih.gov/pubmed/27280396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2949
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