Overexpression and knockout of miR-126 both promote leukemogenesis

It is generally assumed that gain- and loss-of-function manipulations of a functionally important gene should lead to the opposite phenotypes. We show in this study that both overexpression and knockout of microRNA (miR)-126 surprisingly result in enhanced leukemogenesis in cooperation with the t(8;...

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Vydáno v:Blood
Hlavní autoři: Li, Zejuan, Chen, Ping, Su, Rui, Li, Yuanyuan, Hu, Chao, Wang, Yungui, Arnovitz, Stephen, He, Miao, Gurbuxani, Sandeep, Zuo, Zhixiang, Elkahloun, Abdel G., Li, Shenglai, Weng, Hengyou, Huang, Hao, Neilly, Mary Beth, Wang, Shusheng, Olson, Eric N., Larson, Richard A., Le Beau, Michelle M., Zhang, Jiwang, Jiang, Xi, Wei, Minjie, Jin, Jie, Liu, Paul P., Chen, Jianjun
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2015
Témata:
Myeloid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4616234/
https://ncbi.nlm.nih.gov/pubmed/26361793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-04-639062
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