Overexpression and knockout of miR-126 both promote leukemogenesis

It is generally assumed that gain- and loss-of-function manipulations of a functionally important gene should lead to the opposite phenotypes. We show in this study that both overexpression and knockout of microRNA (miR)-126 surprisingly result in enhanced leukemogenesis in cooperation with the t(8;...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Li, Zejuan, Chen, Ping, Su, Rui, Li, Yuanyuan, Hu, Chao, Wang, Yungui, Arnovitz, Stephen, He, Miao, Gurbuxani, Sandeep, Zuo, Zhixiang, Elkahloun, Abdel G., Li, Shenglai, Weng, Hengyou, Huang, Hao, Neilly, Mary Beth, Wang, Shusheng, Olson, Eric N., Larson, Richard A., Le Beau, Michelle M., Zhang, Jiwang, Jiang, Xi, Wei, Minjie, Jin, Jie, Liu, Paul P., Chen, Jianjun
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2015
Fag:
Myeloid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4616234/
https://ncbi.nlm.nih.gov/pubmed/26361793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-04-639062
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