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Acetylation within the First 17 Residues of Huntingtin Exon 1 Alters Aggregation and Lipid Binding
Huntington’s disease (HD) is a genetic neurodegenerative disorder caused by an expanded polyglutamine (polyQ) domain near the N-terminus of the huntingtin (htt) protein. Expanded polyQ leads to htt aggregation. The first 17 amino acids (Nt(17)) in htt comprise a lipid-binding domain that undergoes a...
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| Vydáno v: | Biophys J |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The Biophysical Society
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4968481/ https://ncbi.nlm.nih.gov/pubmed/27463137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.06.018 |
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