Acetylation within the First 17 Residues of Huntingtin Exon 1 Alters Aggregation and Lipid Binding

Huntington’s disease (HD) is a genetic neurodegenerative disorder caused by an expanded polyglutamine (polyQ) domain near the N-terminus of the huntingtin (htt) protein. Expanded polyQ leads to htt aggregation. The first 17 amino acids (Nt(17)) in htt comprise a lipid-binding domain that undergoes a...

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Vydáno v:Biophys J
Hlavní autoři: Chaibva, Maxmore, Jawahery, Sudi, Pilkington, Albert W., Arndt, James R., Sarver, Olivia, Valentine, Stephen, Matysiak, Silvina, Legleiter, Justin
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2016
Témata:
Membranes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968481/
https://ncbi.nlm.nih.gov/pubmed/27463137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.06.018
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