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Acetylation within the First 17 Residues of Huntingtin Exon 1 Alters Aggregation and Lipid Binding

Huntington’s disease (HD) is a genetic neurodegenerative disorder caused by an expanded polyglutamine (polyQ) domain near the N-terminus of the huntingtin (htt) protein. Expanded polyQ leads to htt aggregation. The first 17 amino acids (Nt(17)) in htt comprise a lipid-binding domain that undergoes a...

詳細記述

保存先:
書誌詳細
出版年:Biophys J
主要な著者: Chaibva, Maxmore, Jawahery, Sudi, Pilkington, Albert W., Arndt, James R., Sarver, Olivia, Valentine, Stephen, Matysiak, Silvina, Legleiter, Justin
フォーマット: Artigo
言語:Inglês
出版事項: The Biophysical Society 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968481/
https://ncbi.nlm.nih.gov/pubmed/27463137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.06.018
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