CD99 regulates neural differentiation of Ewing sarcoma cells through miR-34a-Notch-mediated control of NF-kB signaling

Sarcomas are mesenchymal tumors characterized by blocked differentiation process. In Ewing sarcoma (EWS) both CD99 and EWS-FLI1 concur to oncogenesis and inhibition of differentiation. Here we demonstrate that uncoupling CD99 from EWS-FLI1 by silencing the former, NF-kB signaling is inhibited and th...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Oncogene
Main Authors: Ventura, Selena, Aryee, Dave NT, Felicetti, Federica, De Feo, Alessandra, Mancarella, Caterina, Manara, Maria Cristina, Picci, Piero, Colombo, Mario Paolo, Kovar, Heinrich, Carè, Alessandra, Scotlandi, Katia
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967355/
https://ncbi.nlm.nih.gov/pubmed/26616853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.463
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker