CD99 triggering induces methuosis of Ewing sarcoma cells through IGF-1R/RAS/Rac1 signaling

CD99 is a cell surface molecule that has emerged as a novel target for Ewing sarcoma (EWS), an aggressive pediatric bone cancer. This report provides the first evidence of methuosis in EWS, a non-apoptotic form of cell death induced by an antibody directed against the CD99 molecule. Upon mAb trigger...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Manara, Maria Cristina, Terracciano, Mario, Mancarella, Caterina, Sciandra, Marika, Guerzoni, Clara, Pasello, Michela, Grilli, Andrea, Zini, Nicoletta, Picci, Piero, Colombo, Mario P., Morrione, Andrea, Scotlandi, Katia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346761/
https://ncbi.nlm.nih.gov/pubmed/27835596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13160
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