CD99 regulates neural differentiation of Ewing sarcoma cells through miR-34a-Notch-mediated control of NF-kB signaling

Sarcomas are mesenchymal tumors characterized by blocked differentiation process. In Ewing sarcoma (EWS) both CD99 and EWS-FLI1 concur to oncogenesis and inhibition of differentiation. Here we demonstrate that uncoupling CD99 from EWS-FLI1 by silencing the former, NF-kB signaling is inhibited and th...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Ventura, Selena, Aryee, Dave NT, Felicetti, Federica, De Feo, Alessandra, Mancarella, Caterina, Manara, Maria Cristina, Picci, Piero, Colombo, Mario Paolo, Kovar, Heinrich, Carè, Alessandra, Scotlandi, Katia
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967355/
https://ncbi.nlm.nih.gov/pubmed/26616853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.463
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