Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis

Malignant cells exhibit aerobic glycolysis (the Warburg effect) and become dependent on de novo lipogenesis, which sustains rapid proliferation and resistance to cellular stress. The nuclear receptor liver-X-receptor (LXR) directly regulates expression of key glycolytic and lipogenic genes. To disru...

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Udgivet i:Cancer Cell
Main Authors: Flaveny, Colin A., Griffett, Kristine, El-Gendy, Bahaa El-Dien M., Kazantzis, Melissa, Sengupta, Monideepa, Amelio, Antonio L., Chatterjee, Arindam, Walker, John, Solt, Laura A., Kamenecka, Theodore M., Burris, Thomas P.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965273/
https://ncbi.nlm.nih.gov/pubmed/26120082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.05.007
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