Pharmacological Targeting of the Mammalian Clock Regulates Sleep Architecture and Emotional Behavior

Synthetic drug-like molecules that directly modulate the activity of key clock proteins offer the potential to directly modulate the endogenous circadian rhythm and treat diseases associated with clock dysfunction. Here, we demonstrate that synthetic ligands targeting a key component of the mammalia...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Banerjee, Subhashis, Wang, Yongjun, Solt, Laura A., Griffett, Kristine, Kazantzis, Melissa, Amador, Ariadna, El-Gendy, Bahaa M., Huitron-Resendiz, Salvador, Roberts, Amanda J., Shin, Youseung, Kamenecka, Theodore M., Burris, Thomas P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4495958/
https://ncbi.nlm.nih.gov/pubmed/25536025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6759
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