Pharmacological Targeting of the Mammalian Clock Regulates Sleep Architecture and Emotional Behavior

Synthetic drug-like molecules that directly modulate the activity of key clock proteins offer the potential to directly modulate the endogenous circadian rhythm and treat diseases associated with clock dysfunction. Here, we demonstrate that synthetic ligands targeting a key component of the mammalia...

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Pubblicato in:Nat Commun
Autori principali: Banerjee, Subhashis, Wang, Yongjun, Solt, Laura A., Griffett, Kristine, Kazantzis, Melissa, Amador, Ariadna, El-Gendy, Bahaa M., Huitron-Resendiz, Salvador, Roberts, Amanda J., Shin, Youseung, Kamenecka, Theodore M., Burris, Thomas P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4495958/
https://ncbi.nlm.nih.gov/pubmed/25536025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6759
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