Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition

High-grade serous ovarian carcinoma (HGS-OvCa) harbors p53 mutations and can originate from the epithelial cell compartment of the fallopian tube fimbriae. From this site, neoplastic cells detach, survive in the peritoneal cavity, and form cellular clusters that intercalate into the mesothelium to f...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Iwanicki, Marcin P., Chen, Hsing-Yu, Iavarone, Claudia, Zervantonakis, Ioannis K., Muranen, Taru, Novak, Marián, Ince, Tan A., Drapkin, Ronny, Brugge, Joan S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4963159/
https://ncbi.nlm.nih.gov/pubmed/27482544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86829
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