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Chaperone-mediated autophagy degrades mutant p53
Missense mutations in the gene TP53, which encodes p53, one of the most important tumor suppressors, are common in human cancers. Accumulated mutant p53 proteins are known to actively contribute to tumor development and metastasis. Thus, promoting the removal of mutant p53 proteins in cancer cells m...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3744729/ https://ncbi.nlm.nih.gov/pubmed/23913924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.220897.113 |
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