Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death

Hexokinase II (HK2), a key enzyme involved in glucose metabolism, is regulated by growth factor signaling and is required for initiation and maintenance of tumors. Here we show that metabolic stress triggered by perturbation of receptor tyrosine kinase FLT3 in non–acute myeloid leukemia cells sensit...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Xia, Hong-guang, Najafov, Ayaz, Geng, Jiefei, Galan-Acosta, Lorena, Han, Xuemei, Guo, Yuan, Shan, Bing, Zhang, Yaoyang, Norberg, Erik, Zhang, Tao, Pan, Lifeng, Liu, Junli, Coloff, Jonathan L., Ofengeim, Dimitry, Zhu, Hong, Wu, Kejia, Cai, Yu, Yates, John R., Zhu, Zhengjiang, Yuan, Junying, Vakifahmetoglu-Norberg, Helin
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4555813/
https://ncbi.nlm.nih.gov/pubmed/26323688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201503044
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados