Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death

Hexokinase II (HK2), a key enzyme involved in glucose metabolism, is regulated by growth factor signaling and is required for initiation and maintenance of tumors. Here we show that metabolic stress triggered by perturbation of receptor tyrosine kinase FLT3 in non–acute myeloid leukemia cells sensit...

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Udgivet i:J Cell Biol
Main Authors: Xia, Hong-guang, Najafov, Ayaz, Geng, Jiefei, Galan-Acosta, Lorena, Han, Xuemei, Guo, Yuan, Shan, Bing, Zhang, Yaoyang, Norberg, Erik, Zhang, Tao, Pan, Lifeng, Liu, Junli, Coloff, Jonathan L., Ofengeim, Dimitry, Zhu, Hong, Wu, Kejia, Cai, Yu, Yates, John R., Zhu, Zhengjiang, Yuan, Junying, Vakifahmetoglu-Norberg, Helin
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2015
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4555813/
https://ncbi.nlm.nih.gov/pubmed/26323688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201503044
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