Chaperone-mediated autophagy degrades mutant p53

Missense mutations in the gene TP53, which encodes p53, one of the most important tumor suppressors, are common in human cancers. Accumulated mutant p53 proteins are known to actively contribute to tumor development and metastasis. Thus, promoting the removal of mutant p53 proteins in cancer cells m...

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Bibliographische Detailangaben
Hauptverfasser: Vakifahmetoglu-Norberg, Helin, Kim, Minsu, Xia, Hong-guang, Iwanicki, Marcin P., Ofengeim, Dimitry, Coloff, Jonathan L., Pan, Lifeng, Ince, Tan A., Kroemer, Guido, Brugge, Joan S., Yuan, Junying
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2013
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744729/
https://ncbi.nlm.nih.gov/pubmed/23913924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.220897.113
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