Identification of Chalcones as Fasciola hepatica Cathepsin L Inhibitors Using a Comprehensive Experimental and Computational Approach

BACKGROUND: Increased reports of human infections have led fasciolosis, a widespread disease of cattle and sheep caused by the liver flukes Fasciola hepatica and Fasciola gigantica, to be considered an emerging zoonotic disease. Chemotherapy is the main control measure available, and triclabendazole...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Ferraro, Florencia, Merlino, Alicia, dell´Oca, Nicolás, Gil, Jorge, Tort, José F., Gonzalez, Mercedes, Cerecetto, Hugo, Cabrera, Mauricio, Corvo, Ileana
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4962987/
https://ncbi.nlm.nih.gov/pubmed/27463369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004834
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