Identification of Chalcones as Fasciola hepatica Cathepsin L Inhibitors Using a Comprehensive Experimental and Computational Approach

BACKGROUND: Increased reports of human infections have led fasciolosis, a widespread disease of cattle and sheep caused by the liver flukes Fasciola hepatica and Fasciola gigantica, to be considered an emerging zoonotic disease. Chemotherapy is the main control measure available, and triclabendazole...

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Bibliografiska uppgifter
I publikationen:PLoS Negl Trop Dis
Huvudupphovsmän: Ferraro, Florencia, Merlino, Alicia, dell´Oca, Nicolás, Gil, Jorge, Tort, José F., Gonzalez, Mercedes, Cerecetto, Hugo, Cabrera, Mauricio, Corvo, Ileana
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2016
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4962987/
https://ncbi.nlm.nih.gov/pubmed/27463369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004834
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