Substrate Specificity of Cysteine Proteases Beyond the S(2) Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L

Cysteine proteases are widespread in all life kingdoms, being central to diverse physiological processes based on a broad range of substrate specificity. Paralogous Fasciola hepatica cathepsin L proteases are essential to parasite invasion, tissue migration and reproduction. In spite of similarities...

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Detalhes bibliográficos
Publicado no:Front Mol Biosci
Main Authors: Corvo, Ileana, Ferraro, Florencia, Merlino, Alicia, Zuberbühler, Kathrin, O'Donoghue, Anthony J., Pastro, Lucía, Pi-Denis, Natalia, Basika, Tatiana, Roche, Leda, McKerrow, James H., Craik, Charles S., Caffrey, Conor R., Tort, José F.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Molecular Biosciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5917446/
https://ncbi.nlm.nih.gov/pubmed/29725596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2018.00040
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