Structural and Functional Relationships in the Virulence-associated Cathepsin L Proteases of the Parasitic Liver Fluke, Fasciola hepatica

The helminth parasite Fasciola hepatica secretes cysteine proteases to facilitate tissue invasion, migration, and development within the mammalian host. The major proteases cathepsin L1 (FheCL1) and cathepsin L2 (FheCL2) were recombinantly produced and biochemically characterized. By using site-dire...

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Detalhes bibliográficos
Main Authors: Stack, Colin M., Caffrey, Conor R., Donnelly, Sheila M., Seshaadri, Amritha, Lowther, Jonathan, Tort, Jose F., Collins, Peter R., Robinson, Mark W., Xu, Weibo, McKerrow, James H., Craik, Charles S., Geiger, Sebastian R., Marion, Rachel, Brinen, Linda S., Dalton, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979170/
https://ncbi.nlm.nih.gov/pubmed/18160404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708521200
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