Identification of Chalcones as Fasciola hepatica Cathepsin L Inhibitors Using a Comprehensive Experimental and Computational Approach

BACKGROUND: Increased reports of human infections have led fasciolosis, a widespread disease of cattle and sheep caused by the liver flukes Fasciola hepatica and Fasciola gigantica, to be considered an emerging zoonotic disease. Chemotherapy is the main control measure available, and triclabendazole...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Negl Trop Dis
Prif Awduron: Ferraro, Florencia, Merlino, Alicia, dell´Oca, Nicolás, Gil, Jorge, Tort, José F., Gonzalez, Mercedes, Cerecetto, Hugo, Cabrera, Mauricio, Corvo, Ileana
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2016
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4962987/
https://ncbi.nlm.nih.gov/pubmed/27463369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004834
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