Altered Type II Interferon Precedes Autoantibody Accrual and Elevated Type I Interferon Activity Prior to Systemic Lupus Erythematosus Classification

OBJECTIVES: The relationship of immune dysregulation and autoantibody production that may contribute to systemic lupus erythematosus (SLE) pathogenesis is unknown. This study evaluates the individual and combined contributions of autoantibodies, type I interferon (IFN-α) activity, and IFN-associated...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Munroe, Melissa E., Lu, Rufei, Zhao, Yan D., Fife, Dustin A., Robertson, Julie M., Guthridge, Joel M., Niewold, Timothy B., Tsokos, George C., Keith, Michael P., Harley, John B., James, Judith A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959992/
https://ncbi.nlm.nih.gov/pubmed/27088255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2015-208140
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