Altered Type II Interferon Precedes Autoantibody Accrual and Elevated Type I Interferon Activity Prior to Systemic Lupus Erythematosus Classification

OBJECTIVES: The relationship of immune dysregulation and autoantibody production that may contribute to systemic lupus erythematosus (SLE) pathogenesis is unknown. This study evaluates the individual and combined contributions of autoantibodies, type I interferon (IFN-α) activity, and IFN-associated...

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Publicat a:Ann Rheum Dis
Autors principals: Munroe, Melissa E., Lu, Rufei, Zhao, Yan D., Fife, Dustin A., Robertson, Julie M., Guthridge, Joel M., Niewold, Timothy B., Tsokos, George C., Keith, Michael P., Harley, John B., James, Judith A.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959992/
https://ncbi.nlm.nih.gov/pubmed/27088255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2015-208140
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