Shutdown of HIV-1 Transcription in T Cells by Nullbasic, a Mutant Tat Protein

Nullbasic is a derivative of the HIV-1 transactivator of transcription (Tat) protein that strongly inhibits HIV-1 replication in lymphocytes. Here we show that lentiviral vectors that constitutively express a Nullbasic-ZsGreen1 (NB-ZSG1) fusion protein by the eEF1α promoter led to robust long-term i...

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Bibliographic Details
Published in:mBio
Main Authors: Jin, Hongping, Li, Dongsheng, Sivakumaran, Haran, Lor, Mary, Rustanti, Lina, Cloonan, Nicole, Wani, Shivangi, Harrich, David
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958243/
https://ncbi.nlm.nih.gov/pubmed/27381288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00518-16
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