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Strong In Vivo Inhibition of HIV-1 Replication by Nullbasic, a Tat Mutant
Nullbasic is a mutant form of the HIV-1 transcriptional activator protein (Tat) that strongly inhibits HIV-1 transcription and replication in lymphocytes in vitro. To investigate Nullbasic inhibition in vivo, we employed an NSG mouse model where animals were engrafted with primary human CD4(+) cells...
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| Publicado en: | mBio |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6712395/ https://ncbi.nlm.nih.gov/pubmed/31455650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01769-19 |
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