A Mutant Tat Protein Inhibits HIV-1 Reverse Transcription by Targeting the Reverse Transcription Complex

Previously, we reported that a mutant of Tat referred to as Nullbasic inhibits HIV-1 reverse transcription although the mechanism of action is unknown. Here we show that Nullbasic is a reverse transcriptase (RT) binding protein that targets the reverse transcription complex rather than directly inhi...

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Bibliographic Details
Published in:J Virol
Main Authors: Lin, Min-Hsuan, Apolloni, Ann, Cutillas, Vincent, Sivakumaran, Haran, Martin, Sally, Li, Dongsheng, Wei, Ting, Wang, Rui, Jin, Hongping, Spann, Kirsten, Harrich, David
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403448/
https://ncbi.nlm.nih.gov/pubmed/25673710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03440-14
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