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Prevalent, dynamic, and conserved R-loop structures associate with specific epigenomic signatures in mammals

R-loops are three-stranded nucleic acid structures formed upon annealing of an RNA strand to one strand of duplex DNA. We profiled R-loops using a high-resolution, strand-specific methodology in human and mouse cell types. R-loops are prevalent, collectively occupying up to 5% of mammalian genomes....

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Bibliografiske detaljer
Udgivet i:Mol Cell
Main Authors: Sanz, Lionel A., Hartono, Stella R., Lim, Yoong Wearn, Steyaert, Sandra, Rajpurkar, Aparna, Ginno, Paul A., Xu, Xiaoqin, Chédin, Frédéric
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955522/
https://ncbi.nlm.nih.gov/pubmed/27373332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.05.032
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