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High-resolution, strand-specific R-loop mapping via S9.6-based DNA:RNA ImmunoPrecipitation and high-throughput sequencing.
R-loops are prevalent three-stranded non-B DNA structures composed of an RNA:DNA hybrid and a single-strand of DNA. R-loops are implicated in various basic nuclear processes such as class-switch recombination, transcription termination and chromatin patterning. Perturbations in R-loop metabolism hav...
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| 出版年: | Nat Protoc |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6615061/ https://ncbi.nlm.nih.gov/pubmed/31053798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41596-019-0159-1 |
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