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Prevalent, dynamic, and conserved R-loop structures associate with specific epigenomic signatures in mammals
R-loops are three-stranded nucleic acid structures formed upon annealing of an RNA strand to one strand of duplex DNA. We profiled R-loops using a high-resolution, strand-specific methodology in human and mouse cell types. R-loops are prevalent, collectively occupying up to 5% of mammalian genomes....
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4955522/ https://ncbi.nlm.nih.gov/pubmed/27373332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.05.032 |
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