Transcription-Associated R-Loop Formation across the Human FMR1 CGG-Repeat Region

Expansion of a trinucleotide (CGG) repeat element within the 5′ untranslated region (5′UTR) of the human FMR1 gene is responsible for a number of heritable disorders operating through distinct pathogenic mechanisms: gene silencing for fragile X syndrome (>200 CGG) and RNA toxic gain-of-function f...

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Detaylı Bibliyografya
Asıl Yazarlar: Loomis, Erick W., Sanz, Lionel A., Chédin, Frédéric, Hagerman, Paul J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990486/
https://ncbi.nlm.nih.gov/pubmed/24743386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004294
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