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Transcription-Associated R-Loop Formation across the Human FMR1 CGG-Repeat Region
Expansion of a trinucleotide (CGG) repeat element within the 5′ untranslated region (5′UTR) of the human FMR1 gene is responsible for a number of heritable disorders operating through distinct pathogenic mechanisms: gene silencing for fragile X syndrome (>200 CGG) and RNA toxic gain-of-function f...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3990486/ https://ncbi.nlm.nih.gov/pubmed/24743386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004294 |
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