Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu(4))

Lignende værker

• Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu(1)
  af: Manka, Jason T., et al.
  Udgivet: (2013)
• Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu(4)) antagonist: Unexpected ‘molecular switch’ from a closely related mGlu(4) positive allosteric modulator
  af: Utley, Thomas, et al.
  Udgivet: (2011)
• Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy
  af: Gogliotti, Rocco D., et al.
  Udgivet: (2016)
• Solution-Phase Parallel Synthesis and SAR of Homopiperazinyl Analogs as Positive Allosteric Modulators of mGlu(4)
  af: Cheung, Yiu-Yin, et al.
  Udgivet: (2011)
• mGlu(5) Positive Allosteric Modulators Facilitate Long-Term Potentiation via Disinhibition Mediated by mGlu(5)-Endocannabinoid Signaling
  af: Xiang, Zixiu, et al.
  Udgivet: (2019)