Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu(4))

Herein we report the synthesis and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as novel positive allosteric modulators of mGlu(4). We detail our work towards finding phenyl replacements for the core scaffold of previously reported phenyl sulfonamides and phenyl su...

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Détails bibliographiques
Publié dans:Bioorg Med Chem Lett
Auteurs principaux: Gogliotti, Rocco D., Blobaum, Anna L., Morrison, Ryan M., Daniels, J. Scott, Salovich, James M., Cheung, Yiu-Yin, Rodriguez, Alice L., Loch, Matthew T., Conn, P. Jeffrey, Lindsley, Craig W., Niswender, Colleen M., Hopkins, Corey R.
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955388/
https://ncbi.nlm.nih.gov/pubmed/27234146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.05.029
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