LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48

OBJECTIVES: Carbapenemases are the most important mechanism responsible for carbapenem resistance in Enterobacteriaceae. Among carbapenemases, OXA-48 presents unique challenges as it is resistant to β-lactam inhibitors. Here, we test the capacity of the compound LN-1-255, a 6-alkylidene-2′-substitut...

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Dettagli Bibliografici
Pubblicato in:J Antimicrob Chemother
Autori principali: Vallejo, Juan A., Martínez-Guitián, Marta, Vázquez-Ucha, Juan C., González-Bello, Concepción, Poza, Margarita, Buynak, John D., Bethel, Christopher R., Bonomo, Robert A., Bou, German, Beceiro, Alejandro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4954921/
https://ncbi.nlm.nih.gov/pubmed/27125555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkw105
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