Therapeutic Efficacy of LN-1-255 in Combination with Imipenem in Severe Infection Caused by Carbapenem-Resistant Acinetobacter baumannii

The carbapenem-hydrolyzing class D β-lactamases (CHDLs) are the main mechanism of carbapenem resistance in Acinetobacter baumannii. CHDLs are not effectively inactivated by clinically available β-lactam-type inhibitors. We have previously described the in vitro efficacy of the inhibitor LN-1-255 in...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Vázquez-Ucha, Juan Carlos, Martínez-Guitián, Marta, Maneiro, María, Conde-Pérez, Kelly, Álvarez-Fraga, Laura, Torrens, Gabriel, Oliver, Antonio, Buynak, John D., Bonomo, Robert A., Bou, Germán, González-Bello, Concepción, Poza, Margarita, Beceiro, Alejandro
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2019
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761515/
https://ncbi.nlm.nih.gov/pubmed/31383666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01092-19
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