Lineage relationship of CD8(+) T cell subsets is revealed by progressive changes in the epigenetic landscape

To better elucidate epigenetic mechanisms that correlate with the dynamic gene expression program observed upon T-cell differentiation, we investigated the genomic landscape of histone modifications in naive and memory CD8(+) T cells. Using a ChIP-Seq approach coupled with global gene expression pro...

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Vydáno v:Cell Mol Immunol
Hlavní autoři: Crompton, Joseph G., Narayanan, Manikandan, Cuddapah, Suresh, Roychoudhuri, Rahul, Ji, Yun, Yang, Wenjing, Patel, Shashank J., Sukumar, Madhusudhanan, Palmer, Douglas C., Peng, Weiqun, Wang, Ena, Marincola, Francesco M., Klebanoff, Christopher A., Zhao, Keji, Tsang, John S., Gattinoni, Luca, Restifo, Nicholas P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947817/
https://ncbi.nlm.nih.gov/pubmed/25914936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2015.32
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