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Knotting and unknotting of a protein in single molecule experiments

Spontaneous folding of a polypeptide chain into a knotted structure remains one of the most puzzling and fascinating features of protein folding. The folding of knotted proteins is on the timescale of minutes and thus hard to reproduce with atomistic simulations that have been able to reproduce feat...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Ziegler, Fabian, Lim, Nicole C. H., Mandal, Soumit Sankar, Pelz, Benjamin, Ng, Wei-Ping, Schlierf, Michael, Jackson, Sophie E., Rief, Matthias
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2016
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941514/
https://ncbi.nlm.nih.gov/pubmed/27339135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600614113
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