Knotting and unknotting of a protein in single molecule experiments

Spontaneous folding of a polypeptide chain into a knotted structure remains one of the most puzzling and fascinating features of protein folding. The folding of knotted proteins is on the timescale of minutes and thus hard to reproduce with atomistic simulations that have been able to reproduce feat...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Ziegler, Fabian, Lim, Nicole C. H., Mandal, Soumit Sankar, Pelz, Benjamin, Ng, Wei-Ping, Schlierf, Michael, Jackson, Sophie E., Rief, Matthias
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941514/
https://ncbi.nlm.nih.gov/pubmed/27339135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600614113
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