Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells

Sphingosine kinases (two isoforms termed SK1 and SK2) catalyse the formation of the bioactive lipid sphingosine 1-phosphate. We demonstrate here that the SK2 inhibitor, ABC294640 (3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide) or the SK1/SK2 inhibitor, SKi (2-(p-hydroxyan...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: McNaughton, Melissa, Pitman, Melissa, Pitson, Stuart M., Pyne, Nigel J., Pyne, Susan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941342/
https://ncbi.nlm.nih.gov/pubmed/26934645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7693
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