Pharmacology and Antitumor Activity of ABC294640, a Selective Inhibitor of Sphingosine Kinase-2

Sphingolipid-metabolizing enzymes control the dynamic balance of the cellular levels of important bioactive lipids, including the apoptotic compound ceramide and the proliferative compound sphingosine 1-phosphate (S1P). Many growth factors and inflammatory cytokines promote the cleavage of sphingomy...

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Detalhes bibliográficos
Main Authors: French, Kevin J., Zhuang, Yan, Maines, Lynn W., Gao, Peng, Wang, Wenxue, Beljanski, Vladimir, Upson, John J., Green, Cecelia L., Keller, Staci N., Smith, Charles D.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Chemotherapy, Antibiotics, and Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846016/
https://ncbi.nlm.nih.gov/pubmed/20061445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.163444
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