Antiestrogenic Effects of the Novel Sphingosine Kinase-2 Inhibitor ABC294640

Alterations in sphingolipid metabolism have been shown to contribute to the development of endocrine resistance and breast cancer tumor survival. Sphingosine kinase (SK), in particular, is overexpressed in breast cancer and is a promising target for breast cancer drug development. In this study, we...

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Hauptverfasser: Antoon, James W., White, Martin D., Meacham, William D., Slaughter, Evelyn M., Muir, Shannon E., Elliott, Steven, Rhodes, Lyndsay V., Ashe, Hasina B., Wiese, Thomas E., Smith, Charles D., Burow, Matthew E., Beckman, Barbara S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Endocrine Society 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954724/
https://ncbi.nlm.nih.gov/pubmed/20861237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0420
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