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Pharmacological inhibition of sphingosine kinase isoforms alters estrogen receptor signaling in human breast cancer

Recently, crosstalk between sphingolipid signaling pathways and steroid hormones has been illuminated as a possible therapeutic target. Sphingosine kinase (SK), the key enzyme metabolizing pro-apoptotic ceramide to pro-survival sphingosine-1-phosphate (S1P), is a promising therapeutic target for sol...

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Bibliografski detalji
Glavni autori: Antoon, James W, Meacham, William D, Bratton, Melyssa R, Slaughter, Evelyn M, Rhodes, Lyndsay V, Ashe, Hasina B, Wiese, Thomas E, Burow, Matthew E, Beckman, Barbara S
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007162/
https://ncbi.nlm.nih.gov/pubmed/21321095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JME-10-0116
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