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Pharmacological inhibition of sphingosine kinase isoforms alters estrogen receptor signaling in human breast cancer
Recently, crosstalk between sphingolipid signaling pathways and steroid hormones has been illuminated as a possible therapeutic target. Sphingosine kinase (SK), the key enzyme metabolizing pro-apoptotic ceramide to pro-survival sphingosine-1-phosphate (S1P), is a promising therapeutic target for sol...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4007162/ https://ncbi.nlm.nih.gov/pubmed/21321095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JME-10-0116 |
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