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Dual inhibition of sphingosine kinase isoforms ablates TNF-induced drug resistance

Recent research has demonstrated that aberrant sphingolipid signaling is an important mechanism of chemo-resistance in solid tumors. Sphingosine kinase (Sphk), the primary enzyme metabolizing the sphingolipid ceramide into sphingosine-1-phosphate (S1P), is a primary mediator of breast cancer promoti...

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Autors principals: ANTOON, JAMES W., WHITE, MARTIN D., BUROW, MATTHEW E., BECKMAN, BARBARA S.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028227/
https://ncbi.nlm.nih.gov/pubmed/22469881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2012.1743
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