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Dual inhibition of sphingosine kinase isoforms ablates TNF-induced drug resistance
Recent research has demonstrated that aberrant sphingolipid signaling is an important mechanism of chemo-resistance in solid tumors. Sphingosine kinase (Sphk), the primary enzyme metabolizing the sphingolipid ceramide into sphingosine-1-phosphate (S1P), is a primary mediator of breast cancer promoti...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4028227/ https://ncbi.nlm.nih.gov/pubmed/22469881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2012.1743 |
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