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Ablation of Sphingosine Kinase-2 Inhibits Tumor Cell Proliferation and Migration

Sphingosine kinases (SK) regulate the balance between pro-apoptotic ceramides and mitogenic sphingosine-1-phosphate (S1P); however, the functions of the two isoenzymes (SK1 and SK2) in tumor cells are not well defined. Therefore, RNA interference was used to assess the individual roles of SK1 and SK...

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Autori principali: Gao, Peng, Smith, Charles D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219805/
https://ncbi.nlm.nih.gov/pubmed/21896638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-11-0336
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