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Ablation of Sphingosine Kinase-2 Inhibits Tumor Cell Proliferation and Migration
Sphingosine kinases (SK) regulate the balance between pro-apoptotic ceramides and mitogenic sphingosine-1-phosphate (S1P); however, the functions of the two isoenzymes (SK1 and SK2) in tumor cells are not well defined. Therefore, RNA interference was used to assess the individual roles of SK1 and SK...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3219805/ https://ncbi.nlm.nih.gov/pubmed/21896638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-11-0336 |
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