Sphingosine Kinase-2 Inhibition Improves Mitochondrial Function and Survival after Hepatic Ischemia-Reperfusion

BACKGROUND/AIMS: The mitochondrial permeability transition (MPT) and inflammation play important roles in liver injury caused by ischemia-reperfusion (IR). This study investigated the roles of sphingosine kinase-2 (SK2) in mitochondrial dysfunction and inflammation after hepatic IR. METHODS: Mice we...

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Main Authors: Shi, Yanjun, Rehman, Hasibur, Ramshesh, Venkat K., Schwartz, Justin, Liu, Qinlong, Krishnasamy, Yasodha, Zhang, Xun, Lemasters, John J., Smith, Charles D., Zhong, Zhi
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220779/
https://ncbi.nlm.nih.gov/pubmed/21756852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2011.05.025
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