Activation of the oxygen-sensing signal cascade prevents mitochondrial injury after mouse liver ischemia-reperfusion

The mitochondrial permeability transition (MPT) plays an important role in hepatocyte death caused by ischemia-reperfusion (IR). This study investigated whether activation of the cellular oxygen-sensing signal cascade by prolyl hydroxylase inhibitors (PHI) protects against the MPT after hepatic IR....

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Autori principali: Zhong, Zhi, Ramshesh, Venkat K., Rehman, Hasibur, Currin, Robert T., Sridharan, Vijayalakshmi, Theruvath, Tom P., Kim, Insil, Wright, Gary L., Lemasters, John J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2008
Soggetti:
Liver and Biliary Tract
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575910/
https://ncbi.nlm.nih.gov/pubmed/18772364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.90287.2008
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